MOTS-C

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a mitochondrial-derived peptide studied for its role in cellular metabolism and energy regulation. It is encoded within mitochondrial DNA and has been investigated for its involvement in metabolic signaling pathways.

In research models, MOTS-C has been examined for its effects on glucose metabolism, insulin sensitivity, mitochondrial function, and AMP-activated protein kinase (AMPK) activation. It is of particular interest in studies exploring metabolic health, stress adaptation, and age-related cellular changes.